The Yin and Yang of Cholesteryl Ester Transfer Protein in Cardiovascular Disease
نویسندگان
چکیده
منابع مشابه
The yin and yang of cholesteryl ester transfer protein in cardiovascular disease.
Cholesteryl ester transfer protein (CETP) is a 79-kDa glycoprotein, present in humans, rabbits, primates, and hamsters but absent in rodents, dogs, horses, cows, and pigs, that facilitates transfer of cholesteryl ester from high-density lipoprotein (HDL) particles to low-density lipoprotein (LDL)–very-low-density lipoprotein (vLDL) particles in exchange for triglycerides, thereby participating ...
متن کاملThe Yin and Yang of cholesteryl ester transfer protein and atherosclerosis.
Of late, there has been a major renewal of interest into the protective effect of high-density lipoprotein (HDL)cholesterol on atherogenesis and coronary disease [1,2]. This derives from the ability of HDL to transport cholesterol from peripheral tissue back to the liver [i.e. reverse cholesterol transport (RCT)] and from specific anti-atherogenic properties of HDL, including antioxidant, antit...
متن کاملI405V and -629C/A Polymorphisms of the Cholesteryl Ester Transfer Protein Gene in Patients with Coronary Artery Disease
Background: Cholesteryl ester transfer protein (CETP) plays a main role in high-density lipoprotein metabolism. CETP gene possesses several single nucleotide polymorphisms which have been associated with plasma high-density lipoprotein cholesterol (HDL-C) concentrations. The aim of this study was to determine the association of CETP -629C/A and I405V polymorphisms with coronary artery disease (...
متن کاملAssociation of Circulating Cholesteryl Ester Transfer Protein Activity With Incidence of Cardiovascular Disease in the Community
Background—Plasma high-density lipoprotein cholesterol concentration is related inversely to the risk of cardiovascular disease (CVD). Inhibiting cholesteryl ester transfer protein (CETP) activity raises high-density lipoprotein cholesterol and may be cardioprotective, but an initial clinical trial with a CETP inhibitor was stopped prematurely because of increased CVD in treated patients, raisi...
متن کاملPlasma cholesteryl ester transfer protein.
The plasma lipoproteins are continuously remodeled during their transit through the plasma compartment, owing to the action of lipid metabolizing enzymes and lipid transfer processes. These activities have a major effect on the composition, size, and concentration of the lipoproteins. Lipid transfer processes involving neutral lipids and phospholipids are mediated by specialized plasma proteins...
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ژورنال
عنوان ژورنال: Circulation
سال: 2009
ISSN: 0009-7322,1524-4539
DOI: 10.1161/circulationaha.109.910133